Microcontact and UV-NIL fabrication platforms
Microcontact printer and nanoimprint fabrication platform
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Electrocaloric flow sensors
Microelectrode array/flow cells
µArray + liquid handling
µContact + NIL
Microcontact printer and nanoimprint fabrication platform
Donut-shaped chambers for analysis of biochemical processes at the cellular and subcellular levels
Picoliter nDEP traps enable time-resolved contactless single bacterial cell analysis in controlled microenvironments
Process optimization and biocompatibility of cell carriers suitable for automated magnetic manipulation
The individual-cell-based cryo-chip for the cryopreservation, manipulation and observation of spatially identifiable cells.
DNA microarrays for hybridization detection by surface plasmon resonance spectroscopy
A polymer microstructure array for the formation, culturing, and high throughput drug screening of breast cancer spheroids. Biomaterials.
Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure
µCP4.1 LINE ITEMS
A053-205 Micro-Contact Printer µCP 4.1
A051-210 Cartridge heater for 10ml cartridges
A051-212 Stainless steel cartridge 10 mL
A051-213 Luer Lock Adapter for stainless steel cartridge
A051-702 Dispense needle 0,25 mm, stainless steel
A051-286 Piezoelectric Pipetting Tip Nano-Tip J-H, heatable, RevB
A051-410 Heatable micro plate holder 60°C for pipetting module
A040-661 µCP Spacer, PEEK, 10x10
A040-662 µCP Spacer, PEEK, 20x20
A040-030a 4inch-Si-Master, max. depth 45 micron, Teflon coated
NEW DESIGN ; pattern with lateral resolution >/=2µm
A040-030b 4inch-Si-Master, max. depth 45 micron, Teflon coated
AVAILABLE DESIGN e.g. CellPROM
The µContactPrinter systems replicate stamp patterns in soft polymers. It is a versatile benchtop instrument for doing microfluidics by nanoimprint lithography (NIL) and surface patterning on the nanoscale.
Few simple techniques exist to produce tiny patterns on a surface. One method, microarray spotting (e.g. with the
) generates a resolution of approx. 100 µm. Microcontact printing (µCP) does work on the nanoscale: a soft polymer like PDMS (silicone) is cast on a micro- or nanostructured master; the resulting stamp is soaked in sample and pressed onto a surface, thus transferring molecules from the protruding areas.
Chemicals, biomolecules, nanoparticles, beads and cells
can be printed, which is why µCP is getting popular in the life sciences, e.g. to study the influence of structured matrix proteins or growth factors on growth, differentiation and movement of cells.
µCP and NIL are easily performed on the fully automatic GeSiM µContactPrinter 4.1, taking the risk out of both methods. Smaller structures can be tiled together via step & repeat, especially when using “double-side patterning” with a silicon mask in the stamp. For higher throughput, the larger µCP 4.2 exists that comes with linear motor and a UV collimator on the lower level, for research and medium-scale production.
Options for NIL
Temperature controlled substrate holder,
UV illumination for curing
Double-side patterning using a silicon aperture for accurate structuring of the shape of the imprinted polymer by UV curing
µCP 4.1 Properties
XYZ robotics, belt-driven
Repeating accuracy of mechanics < 5 µm
Individually controlled multi-Z-drives with various tools, stamping unit and cartridge/ powder/piezo/capillary dispensers, etc.
Stamp drive: automatic pickup of stamp holder from rack, head turnable by ±5°
Stamp diameters: 5, 10, 15, 20 mm (max.), and customized
Substrate holder: wafer size (10 cm / 4"), vacuum fixation, with ceramic heater / air-cooling
Sensors for stamp Z-position, substrate Z-height, and positions of dispenser tips
Microscope in print head, background illumination, automatic image processing to find and align fiducial marks
Liquid handling by capillary dispenser (for µl volumes) and/or piezoelectric ink-jet dispenser (for nl volumes)
Microplate holder, cooled / heated by external recirculation thermostat
UV source with optical fibre for NIL
Extras: cartridge holder for adhesive printing , powder dispenser for µg quantities, microfluidic flow-through stamp for "negative" print, "double-side patterning" stamps and casting station
Windows control software, pre-configured, on computer. Periphery: 115 or 230 V AC, compressed air or nitrogen (max. 1 MPa), vacuum if needed. Requirements: filtered compressed air or nitrogen (max. 1 MPa), vacuum if needed, 115 – 240 V AC, enclosure or fume hood or biological safety cabinet
For more info, please see product
or check out master
Click image to expand view
µCP 4.1 workstations: rack for stamps, spin coater for inking (with stamp height sensor), substrate holder with vacuum fixation, tool for tip alignment, turnable print head, plus ink-jet dispenser, Z-sensor and cartridge holder. Wash/dry stations, MTP holder and stroboscope (behind dry station) are for ink-jet dispensing. membrane in stamp frame
The Making of Micro- and Nanostructures in 2D and 3D
Stamp casting station (left) and ready to use stamp membrane in stamp frame
µCP 4.2 (two-level instrument) with fast linear motor in X-direction; the lower Y-axis normally contains a UV collimator for homogeneous irraddiation. The flexible design of the µCP platform allows complete reconfiguration.
Microcontact printing: left, PDMS stamp; right, fluorescein- and rhodamine-labelled fibronectin pads, printed side by side on glass. Bar: 50 µm.
Crosshairs on a chip, aligned (X/Y/Z/angle) with complementary structure on stamp
Nanoimprinting experiments: nanoimprinted picowells, 250 µm diameter (left), and 200 nm wide pillars of a plasmonic sensor
UV illumination set up for nanoimprinting
GeSiM µCP principle. The stamp membrane in its frame is bulged out when contacting the surface, resulting in defined pressure and even transfer
A casting station for stamp moulding is included. Customized, teflonised silicon masters with structures as small as 100 nm are
. Other stamp materials can be used as well, e.g. the stiffer PFPE for structures < 500 nm with high aspect ratio.
Example automated process
The stamp can move in XYZ and rotate
A microscope built into the print head is used for manual or automatic alignment of stamp and substrate
Controlled inflation of the polymer stamp before and during printing
Pressure increase after surface contact is possible, especially for NIL